FIGURE

Figure 4.

ID

ZDB-FIG-240206-51

Publication

Wright et al., 2024 - Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection

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Figure 4.

Modulation of Tsc1 alters key host defence and inflammatory pathways.

(A) Heatmap of differentially expressed genes (DEGs) identified by RNA sequencing of 3 dpf embryos after CRISPR-Cas9 knockdown of tsc1a. (B) Enrichment score mapping to the term MTOR signalling pathway of DEG identified by RNA sequencing of 3 dpf embryos after CRISPR-Cas9 knockdown of tsc1a. (C) Heatmap of DEGs identified by RNA sequencing of 3 dpi embryos after CRISPR-Cas9 knockdown of tsc1a and infection with M. marinum. (D) Volcano plot of DEGs identified by RNA sequencing of 3 dpi embryos after CRISPR-Cas9 knockdown of tsc1a and infection with M. marinum. Up-regulated host defence and inflammatory pathway genes are annotated. (E, F) Gene ontology analysis was performed on DEGs identified by RNA sequencing of 3 dpi embryos after CRISPR-Cas9 knockdown of tsc1a and infection with M. marinum to identify key downstream pathways either increased (E) or decreased (F) in tsc1a crispants.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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