FIGURE

Figure 2

ID

ZDB-FIG-240129-198

Publication

Qian et al., 2023 - Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease

Other Figures

All Figure Page

Back to All Figure Page

Figure 2

Alteration of the retinal vasculature in aldh9a1b^−/− mutants (A) Graphical overview of phenotype exploration in aldh9a1b^−/‐ zebrafish. B) Representative confocal images of hyaloid vasculature showed vascular alterations in aldh9a1b^−/‐ larvae at 5dpf. Red arrows, sprouts; yellow circles, branch points. White scale bar = 50 µm. C) Quantification of increased hyaloid branchpoints and sprouts formation in aldh9a1b^−/‐ larvae, n = 16/18. D) Quantification of increased retinal branch points and sprouts formation in adult aldh9a1b^−/‐ zebrafish. One data point means one 350 µm² square in high‐density retina, n = 8/10. E) Representative confocal images of adult retinal vasculature showed vascular alterations in aldh9a1b^−/‐ zebrafish. Red arrows, sprouts; yellow circles, branch points. White scale bar = 500 µm. The bars indicate mean ± SD values. Statistical analysis was performed by Student's t‐test, ^**p < 0.01, ^****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Adv Sci (Weinh)