Figure 2

Figure 2

Alteration of the retinal vasculature in aldh9a1b^−/− mutants (A) Graphical overview of phenotype exploration in aldh9a1b^−/‐ zebrafish. B) Representative confocal images of hyaloid vasculature showed vascular alterations in aldh9a1b^−/‐ larvae at 5dpf. Red arrows, sprouts; yellow circles, branch points. White scale bar = 50 µm. C) Quantification of increased hyaloid branchpoints and sprouts formation in aldh9a1b^−/‐ larvae, n = 16/18. D) Quantification of increased retinal branch points and sprouts formation in adult aldh9a1b^−/‐ zebrafish. One data point means one 350 µm² square in high‐density retina, n = 8/10. E) Representative confocal images of adult retinal vasculature showed vascular alterations in aldh9a1b^−/‐ zebrafish. Red arrows, sprouts; yellow circles, branch points. White scale bar = 500 µm. The bars indicate mean ± SD values. Statistical analysis was performed by Student's t‐test, ^**p < 0.01, ^****p < 0.0001.