FIGURE

Figure 4

ID

ZDB-FIG-240112-45

Publication

Raman et al., 2023 - A Zebrafish Mutant in the Extracellular Matrix Protein Gene efemp1 as a Model for Spinal Osteoarthritis

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Figure 4

Reduced intervertebral disk space and bone spurs observed in the spine of efemp1−/− adult zebrafish. (A) Closeup view of pre-caudal vertebrae 6–8 (L to R) for wt and efemp1−/−, clearly showing reduced intervertebral disk space and bone spurs, indicated by yellow bar and arrowheads, respectively. (B) Intervertebral disk space calculated between vb06-vb07 and vb07-vb08 (n = 6 fish/group), revealing significant reduction of the intervertebral disk space in the efemp1−/− zebrafish adults. The values are expressed as mean ± SEM, significance: * p < 0.05, ** p < 0.01, as determined by ordinary one-way ANOVA test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	efemp1^{ulg074/ulg074} (AB)
Observed In:	vertebra 6 vertebra 7 vertebra 7 bone tissue vertebra 8 vertebra 8 bone tissue
Stage:	Adult

Phenotype Detail

Acknowledgments

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