FIGURE

Fig 7

ID

ZDB-FIG-240105-70

Publication

Rothschild et al., 2023 - Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish

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Fig 7

Izf1 splicing is altered in rag2:EGFP-CA-CaMKII;tp53 mutant B cells.

Zebrafish ikzf1 was PCR amplified, cloned, and sequenced from the indicated cell fractions. Zebrafish izf1 is encoded by eight alternatively spliced exons with four zinc finger DNA binding domains (blue) and two zinc finger dimerization domains (red). Cell fractions included rag2:DsRed positive, rag2:DsRed;tp53 mutant positive, rag2:EGFP-CA-CaMKII positive, and rag2:EGFP-CA-CaMKII;tp53 mutant positive B cells. The “x” indicates expression of the particular ikzf1 splice variant in fluorescently sorted kidney marrow B cells. Ikvar3-7 resulted from frameshifts that induced premature stop codons (S4 Table).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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