FIGURE

Fig 1

ID

ZDB-FIG-240105-64

Publication

Rothschild et al., 2023 - Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish

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Fig 1

Transgenic expression of human (Hsa) constitutively active (T287D, CA) EGFP-CA-CaMKII in lymphocytes of zebrafish.

(A) Diagram of the rag2:EGFP-CA-CaMKII construct. (B, C, D, E arrows) Stable rag2:EGFP-CA-CaMKII fish express EGFP in the thymus at 4 dpf, 14 dpf, 60 dpf, and 90 dpf. (F-K) Rag2:EGFP-CA-CaMKII is expressed in both the cytosol and nucleus of (F-H) kidney marrow (KM) and (I-K) spleen lymphocytes counterstained with DAPI at six-months of age. Scale bars: 100 μm in B and C, 400 μm in D and E, and 10 μm in H and K.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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