FIGURE

Fig. 6

ID

ZDB-FIG-231221-30

Publication

Campbell et al., 2023 - Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation

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Fig. 6

mrpl40 and prodha function independently from each other to regulate NSPC proliferation.

Number of Glast−/PH3+ (A) and Glast+/PH3+ (B) cells in mrpl40/prodha transheterozygotes and double mutants compared to single mutants. Double mutants have both prodha and mrpl40 single mutant phenotypes. Transheterozygotes display no phenotypes. Quantification one-way ANOVA, p-values are displayed on the plots. siblings (n = 20), transheterozygotes (n = 20), mrpl40 mutants (n = 10), prodha mutants (n = 10) and mrpl40;prodha double mutants (n = 9) from four biological replicates. PH3 staining in Tg(slc1a3b:H2AmCherry) line in wildtype (C), single prodha mutants (D), and double mutants (E). Double mutant has more severe hyperproliferative phenotype, revealing role for mrpl40 in Glast+ NSPCs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Psychiatry