FIGURE 5

Gene expression between control, vehicle, MPTP and NT3 treatment groups. There was a significant downregulation in th1 gene expression in MPTP.3, which was reversed with NT3 treatment. dat gene has similar pattern with th2, where there was a steep increase in expression in dat in the MPTP group over 10 days, while the NT3 treatment group had a rather fluctuating pattern. dat gene was upregulated in NT3.3 group compared to the corresponding MPTP.3.NT3.3 group has been shown to reverse the downregulation of bdnf in the corresponding PD model and become equivocal to the vehicle group. Like bdnf, the ntf3 gene was downregulated in MPTP.3. Following that, a steady increase in gene regulation in MPTP.5 and MPTP.10 became equivocal to the vehicle group and the NT3 groups. # describes the significant difference between the MPTP and vehicle groups with #p < 0.05, ##p < 0.01; * describes the statistically significant difference between the NT3 treatment group and its corresponding MPTP group with *p < 0.05, and **p < 0.01; α describes the significant difference between the NT3 group and the vehicle with α p < 0.05, αα p < 0.01; κ describes the significant difference between NT3.3, NT3.5 and NT3.5 with κ p < 0.05 and κκ p < 0.01.