FIGURE

Figure 2

ID

ZDB-FIG-231212-29

Publication

Bernal-Bermúdez et al., 2023 - A zebrafish model of Ifih1-driven Aicardi-Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients

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Figure 2

Transcriptomic analysis of the Tg(ifih1_mut) reveals systemic inflammation and an ISG signature upon poly I:C induction. Differentially expressed genes (DEGs) between wild-type larvae and Tg(ifih1_mut)(A), between wild type + Poly I:C and wild-type (B), and between Tg(ifih1_mut) + Poly I:C and wild type + Poly I:C (C). (D, E) Heatmap of analyzed ISGs (D) and proinflammatory genes (E) between Tg(ifih1_mut) + Poly I:C and wild type + Poly I:C represented by counts. (F, G) GO (F) and KEGG (G) analysis between Tg(ifih1_mut) + Poly I:C and wild type + Poly I:C.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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