FIGURE

Fig. 4

ID

ZDB-FIG-231208-30

Publication

Celeghin et al., 2023 - A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes

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Fig. 4

Signalling pathways dysregulation in Dsp mutant adult hearts.

qPCR analysis of the expression of Wnt/β-catenin, YAP-TAZ and TGF-β signalling members showed a downregulation of all pathways in 1-year old Dsp mutant hearts. Each point on the graph corresponds to a pool of 3 hearts of the same genotype. Sample size: n = 12. Log2 FC: Log2 Fold Change. Error bars: SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Test: Unpaired t-test.

Expression Data

Genes:	ccnd1 ccn2a ccn2b mycbp smad2 smad3a
Fish:	WT dspa^sa13356/+; dspb^ia303/+
Anatomical Term:	heart
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dspa^sa13356/+; dspb^ia303/+
Observed In:	heart
Stage:	Adult

Phenotype Detail

Acknowledgments

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