Gene

smad2

ID
ZDB-GENE-990603-7
Name
SMAD family member 2
Symbol
smad2 Nomenclature History
Previous Names
  • madh2
  • fj43c06
  • SMA- and MAD-related protein 2
  • wu:fj43c06
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including neural plate anterior/posterior regionalization; nodal signaling pathway; and positive regulation of oocyte development. Localizes to chromatin and nucleus. Is expressed in brain; head; immature eye; and tail bud. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smad2 Human Ortholog
No data available
Associated With smad2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001132 SMAD domain, Dwarfin-type
Domain IPR003619 MAD homology 1, Dwarfin-type
Domain IPR013019 MAD homology, MH1
Family IPR013790 Dwarfin
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036578 SMAD MH1 domain superfamily
Domain Details Per Protein
Protein Length Dwarfin MAD homology 1, Dwarfin-type MAD homology, MH1 SMAD domain, Dwarfin-type SMAD/FHA domain superfamily SMAD-like domain superfamily SMAD MH1 domain superfamily
UniProtKB:Q9I9P9 468
UniProtKB:E9QJE3 160
UniProtKB:Q7ZU35 468
UniProtKB:F1Q5P5 469
UniProtKB:E9QE59 74
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab-smad2 polyclonal Rabbit
  • IHC
  • WB
Cell Signaling Technology, Inc.
13
Ab2-smad2 monoclonal IgG Rabbit
  • IHC
Millipore
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations