ZFIN ID: ZDB-GENE-990603-7
Gene Name: SMAD family member 2
Gene Symbol: smad2    Nomenclature History

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Previous Names: madh2, fj43c06, SMA- and MAD-related protein 2, wu:fj43c06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neural plate anterior/posterior regionalization; and positive regulation of oocyte development. Predicted to localize to nucleus. Is expressed in brain; head; immature eye; and tail bud. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2).
Genome Resources: Alliance (1),  Gene:30639 (1),  Ensembl(GRCz11):ENSDARG00000006389 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 9 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55212]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21685 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu99 Point Mutation Exon 9 Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-smad2
    1
    MO1-smad2 N/A 3
    MO2-smad2 N/A 3
    MO3-smad2 N/A 1
    MO4-smad2 N/A 1
    DISEASE ASSOCIATED WITH smad2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH smad2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smad2-202 (1)    Ensembl 1994
    smad2-204 (1)    Ensembl 555
    smad2-205 (1)    Ensembl 812
    smad2-206 (1)    Ensembl 1949
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab-smad2 polyclonal Rabbit IHC, WB Cell Signaling Technology, Inc.
    13
    Ab2-smad2 monoclonal IgG Rabbit IHC Millipore
    6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smad2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actb2:EGFP-smad2) actb2 EGFPsmad2 Danio rerio 1 4
    Tg(ubb:GFP-smad2) ubb GFPsmad2 Danio rerio 1 1
    Tg(Xla.Eef1a1:Venus-smad2) smad2Venus Danio rerioXenopus laevis 1 2
    MARKER RELATIONSHIPS
    smad2 Contained in: [BAC] DKEY-88L16 (1) (order this), DKEY-126N10 (1) (order this)
    smad2 Encodes: [EST] fj43c06
    [cDNA] MGC:55212 (1), MGC:113963 (1), MGC:192434 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001290015 (1) 3895 nt
    Genomic GenBank:CR536613 (1) 174800 nt
    Select Tool
    Polypeptide UniProtKB:F1Q5P5 (1) 469 aa
    Sequence Information (all 35)
    ORTHOLOGY for smad2 ( Chr: 10 )
    CITATIONS (78)