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FIGURE 6

ID

ZDB-FIG-231201-6

Publication

Guzelkaya et al., 2023 - A zebrafish model for studying the mechanisms of newborn hyperbilirubinemia and bilirubin-induced neurological damage

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FIGURE 6

Bilirubin-induced neurological damage (BIND) is detected in the larval brain:(A) Apoptotic cells were detected in the brains of control and hyperbilirubinemia larvae at 4 dpf. DAPI (blue) highlights the brain structure, and cleaved caspase 3 (C-Casp3) (red) labels apoptotic cells. Dorsal views of fore brain (left) and hind brain (right) are shown for control, 9 μM and 15 µM bilirubin treatment groups. (B–F) H&E-stained paraffin sections of 6 dpf larval brains. (A) Intact and healthy brain tissue in control larva; deformed brain tissue in larvae that received (B) 9 µM or (C) 15 µM bilirubin between 2–3 dpf. (D) Larva that received 9 µM bilirubin between 3 - 4 dpf had normal brain tissue. (E) Larva that was exposed to 15 µM bilirubin between 3–4 dpf had slight deformation in brain tissue. Scale bars: 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol