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FIGURE 2

ID

ZDB-FIG-231201-2

Publication

Guzelkaya et al., 2023 - A zebrafish model for studying the mechanisms of newborn hyperbilirubinemia and bilirubin-induced neurological damage

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FIGURE 2

Mild and severe phenotypes: The larvae exposed to 9 µM bilirubin between 2–3 dpf display (A) mild or (B) severe phenotypes at 4 dpf. Close-up images are shown next to the overview images. navy, blue and red arrows represent bilirubin, yolk edema and pericardial edema, respectively. The green arrow indicates bilirubin excreted from the GI tract. Scale bars: 200 µm. (C) Average body length of larvae treated with bilirubin at 2–3 dpf for 24 h (purple line) or at 2–4 dpf for 48 h (pink line) shows a significant shortening of body length upon 9–15 µM bilirubin exposure. (D–F) Penetrance of the severe phenotype after exposure to bilirubin between (D) 2–3 dpf, (E) 2–4 dpf and (F) 3 - 4 dpf. Larvae were treated with vehicle, 3 μM, 6 μM, 9 µM or 15 µM bilirubin. The mean ± SEM was calculated from triplicate treatments of 15 larvae in each group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol