FIGURE

Figure 6

ID

ZDB-FIG-231127-93

Publication

Deng et al., 2023 - Dynamic Regulation of brsk2 in the Social and Motor Development of Zebrafish: A Developmental Behavior Analysis

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Figure 6

brsk2ab^−/− zebrafish displayed escalating anxiety-like behaviors. (A) The analytical paradigm showed that the open field tank was divided into two equal zones, and the thigmotaxis was calculated using the time and distance ratio that fish spent in the peripheral zone. (B) There was no significant difference in the thigmotaxis index between WT and brska2b⁻^/⁻ zebrafish at 2 mpf (WT vs. brsk2ab^−/−, n = 20: 27, distance: 0.7737 ± 0.14 vs. 0.8376 ± 0.16, p = 0.1622; time: 0.8245 ± 0.13 vs. 0.8712 ± 0.15, p = 0.2225). (C) The thigmotaxis of brsk2ab^−/− zebrafish was observed to have increased more than that of WT zebrafish at 3 mpf (WT vs. brsk2ab^−/−, n = 27: 22, distance: 0.8522 ± 0.05 vs. 0.9274 ± 0.05, p < 0.0001; time: 0.8934 ± 0.05 vs. 0.9389 ± 0.06, p = 0.0038). Data are shown as mean ± SEM s, ** p < 0.01, **** p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	brsk2a^{zf3919/zf3919}; brsk2b^{zf3706/zf3706} (TU)
Observed In:	thigmotaxis
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

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