FIGURE

Fig. 7

ID

ZDB-FIG-231106-52

Publication

Ding et al., 2023 - Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth

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Fig. 7

Photo-triggered suppression of tumor cells by 2 in zebrafish xenografts. (A) The time scheme for the experiments in (C)–(F). MSA-2 (40 μM) and 2 (10 μM) were added to the embryo medium accordingly. (B) Scheme of the tumor cell injection site and subsequent imaging area. (C) Representative confocal images of CT26 tumor cells and innate immune cells from Tg (coro1a:GFP) zebrafish xenografts at 4 dpi treated with MSA-2, 2 and 2 irradiated by light. (D) Relative tumor growth at 4 dpi versus 1 dpi. Results are shown as the mean ± SEM from multiple experiments, n = 9 embryos per group (***p < 0.001, ****p < 0.0001, t-test). (E) Representative confocal images of HT29 tumor cells and innate immune cells from Tg (coro1a:GFP) zebrafish xenografts at 4 dpi treated with MSA-2, 2 and 2 irradiated by light. (F) Relative tumor growth at 4 dpi versus 1 dpi. Results are shown as the mean ± SEM from multiple experiments, n = 9 embryos per group (***p < 0.001, ****p < 0.0001, t-test). Scale bars in (C) and (E): 50 μm; dpf, days post fertilization; dpi, days post injection

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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