FIGURE

Fig. 3

ID

ZDB-FIG-231030-79

Publication

Kolb et al., 2023 - Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment

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Fig. 3

SLRPs are enriched in human brain lesions.

Anti-CHAD, anti-FMOD, anti-LUM, and anti-PRELP immunoreactivity is locally increased in areas of scarring caused by contusion, local hemorrhage, or previous surgery (asterisks indicate lesion center, arrowheads mark scar boundaries) in the human brain, as compared to regions distant to the primary lesion site (hash sign), as well as human brain controls with no signs of fibrotic scarring (see Supplementary Fig. 3). Shown are coronal sections of brain tissue from patients with traumatic brain injury (TBI) or previous surgery (re-OP; bottom panel). Six (n = 6) cases with scars following TBI or previous surgery were analyzed and showed similar results (Supplementary Table 1). Scale bars: 500 µm, 50 µm (insets). The human icon in the panel was created using BioRender.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.