ZFIN Image: Kolb et al., 2023, Fig. 3

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Figure Caption

Fig. 3 SLRPs are enriched in human brain lesions.

Anti-CHAD, anti-FMOD, anti-LUM, and anti-PRELP immunoreactivity is locally increased in areas of scarring caused by contusion, local hemorrhage, or previous surgery (asterisks indicate lesion center, arrowheads mark scar boundaries) in the human brain, as compared to regions distant to the primary lesion site (hash sign), as well as human brain controls with no signs of fibrotic scarring (see Supplementary Fig. 3). Shown are coronal sections of brain tissue from patients with traumatic brain injury (TBI) or previous surgery (re-OP; bottom panel). Six (n = 6) cases with scars following TBI or previous surgery were analyzed and showed similar results (Supplementary Table 1). Scale bars: 500 µm, 50 µm (insets). The human icon in the panel was created using BioRender.

Acknowledgments

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