FIGURE

Figure 3

ID

ZDB-FIG-231030-119

Publication

Huttner et al., 2023 - Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish

Other Figures

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Figure 3

Scfd1 deficiency leads to cardiac dysfunction in zebrafish embryos. Survival, heart rate, ventricular end-diastolic area (EDA) and fractional area change (FAC) are reduced in embryonic hah^vcc43−/− and scfd1^vcc44−/− mutants, while heterozygous siblings of both lines (+/−) are indistinguishable from wildtype (WT; +/+). Non-parametric survival test (Cox-Mantel) and two-way ANOVA p-values stated. Animal numbers, mean values, and multiple comparison p-values for all variables, time points, and genotypes listed in Supplementary Table S2; asterisk indicates significant differences from WT in hah^{vcc4 −/−} and scfd1^vcc44−/− mutants. Significance if p < 0.05. Created with BioRender.com.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scfd1^vcc43/vcc43 scfd1^vcc44/vcc44 scfd1^vcc43/+ scfd1^vcc44/+
Observed In:	heart contraction whole organism
Stage Range:	Day 4 to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cardiovasc Dev Dis