FIGURE

Figure 3.

ID

ZDB-FIG-231012-4

Publication

Oyarbide et al., 2023 - SBDS^R126T rescues survival of sbds^-/- zebrafish in a dose-dependent manner independently of Tp53

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Figure 3.

Phenotype of 10 dpf larvae expressing the human SBDS^R126T.

(A) Western blot showed Eif6 without RPL5, and Rpl11 accumulation in the sbds KO fish, but there was no Eif6 accumulation in the SBDS^R126T strain. (B) Protein quantification of Western blots as performed with NIH ImageJ. (C) After Sudan black staining, neutrophils were counted and found to be significant lower in the sbds KO background with or without the transgene. (D) qRT-PCR analysis of critical genes involved in ribosomal, metabolic, and tp53-associated pathways.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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