FIGURE

Fig. 2

ID

ZDB-FIG-231004-6

Publication

Yong et al., 2023 - Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Structural comparison of metazoan Mon1-Ccz1-RMC1 structure with fungal Mon1-Ccz1 structure. (A) Schematic domain organization of CtMon1-Ccz1 subunits. LDs (LD1 to LD3) are indicated. Ct: Chaetomium thermophile. (B) Cryo-EM structure of CtMon1–Ccz1 complex (PDB:7QLA). LD domains of CtMon1 and CtCcz1 are labeled as indicated. (C) Overlay of the DmMon1–Ccz1–RMC1 complex with the CtMon1–Ccz1 complex. Subunits of metazoan complex are colored as in Fig. 1, and subunits of fungal complex are shown in gray. The 15 α-helices of RMC1 α-solenoid are labeled in order. (D) A zoom-in view of the second α-helix of DmCcz1-LD3 with DmRMC1. (E and F) A zoom-in view of DmMon1 LD2 and LD3 domains with DmRMC1 in comparison with CtMon1. The rotation angle between DmMon1 and CtMon1 is shown as indicated. (G) A zoom-in view of DmCcz1 LD2 domain with DmRMC1 in comparison with CtCcz1. The rotation angle between DmCcz1 and CtCcz1 is shown as indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA