FIGURE

Fig 3

ID

ZDB-FIG-231002-52

Publication

Zhai et al., 2023 - Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis

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Fig 3

Partial rescue of bmp15 deficiency by inha mutation.

(A) Histological examination of gonads at 120 dpf. The follicle development was arrested at PV–EV transition in bmp15-/- females while the double mutant (bmp15-/-;inha-/-) resumed vitellogenic growth to MV stage, not FG stage as seen in inha-/-. (B) Follicle distribution in different genotypes at 120 dpf. The diameters of bmp15 mutant follicles could reach the size of PV stage (~250 μm), while the double mutant (bmp15-/-;inha-/-) follicles could grow beyond PV to reach MV stage (~450 μm). (C) Serum levels of E2 and Vtg in different genotypes at 120 dpf. The E2 and Vtg levels were significantly lower in bmp15-/- females than those in the control, and they were both returned to normal levels in the double mutant (bmp15-/-;inha-/-). The values are expressed as mean ± SEM (n = 5) and analyzed by ANOVA followed by the Tukey HSD for multiple comparisons. Different letters indicate statistical significance (P < 0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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