IMAGE

Fig 3

ID: ZDB-IMAGE-231002-47
Publication: Zhai et al., 2023 - Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis
All Figures: Figures for Zhai et al., 2023

Image

Figure Caption

Fig 3 Partial rescue of bmp15 deficiency by inha mutation.

(A) Histological examination of gonads at 120 dpf. The follicle development was arrested at PV–EV transition in bmp15-/- females while the double mutant (bmp15-/-;inha-/-) resumed vitellogenic growth to MV stage, not FG stage as seen in inha-/-. (B) Follicle distribution in different genotypes at 120 dpf. The diameters of bmp15 mutant follicles could reach the size of PV stage (~250 μm), while the double mutant (bmp15-/-;inha-/-) follicles could grow beyond PV to reach MV stage (~450 μm). (C) Serum levels of E2 and Vtg in different genotypes at 120 dpf. The E2 and Vtg levels were significantly lower in bmp15-/- females than those in the control, and they were both returned to normal levels in the double mutant (bmp15-/-;inha-/-). The values are expressed as mean ± SEM (n = 5) and analyzed by ANOVA followed by the Tukey HSD for multiple comparisons. Different letters indicate statistical significance (P < 0.05).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.