FIGURE

Figure 6

ID

ZDB-FIG-230826-6

Publication

Liao et al., 2023 - Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance

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Figure 6

Zebrafish sirt7 promotes degradation of hif-1αa, hif-1αb, hif-2αa, and hif-2αb.A, Western blot analysis of hif-1αa expression in HEK293T cells transfected with Flag-hif-1αa together with an increased amount of Myc-tagged sirt7. B, Western blot analysis of hif-1αb expression in HEK293T cells transfected with Flag-hif-1αb together with an increased amount of Myc-tagged sirt7. C, Western blot analysis of hif-2αa expression in HEK293T cells transfected with Flag-hif-2αa together with an increased amount of Myc-tagged sirt7. D, Western blot analysis of hif-2αb expression in HEK293T cells transfected with Flag-hif-2αb together with an increased amount of Myc-tagged sirt7. E, Western blot analysis of indicated protein levels in sirt7-null mutant (sirt7^{ihblqs4/ihblqs4}) and the wildtype sibling (sirt7^+/+) (3 dpf). F, Western blot analysis of indicated protein levels in sirt7-null mutant (sirt7^{ihblqs7/ihblqs7}) and the wildtype sibling (sirt7^+/+) (3 dpf).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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