FIGURE

Fig. 4

ID

ZDB-FIG-230614-4

Publication

Grissenberger et al., 2022 - High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-X_L inhibition against Ewing sarcoma

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Fig. 4

Fig. 4. Combination treatments of xenotransplanted larvae Xenotransplanted larvae were treated with A-1331852 (10 ?M), S63845 (5 ?M), irinotecan (5 ?M), YK-4-279 (5 ?M) and respective combinations for 48 h (1 dpi - 3 dpi). A) Representative images for average change in tumor size for every condition. B) Relative change of tumor area (3 dpi/1 dpi). C) Mean absolute tumor sizes and percent changes. Scale bar is 125 ?m. For evaluation, single treatments were compared to DMSO control and combination treatments were compared to respective single treatments (top significance value indicates comparison to first compound, bottom value indicates comparison to second compound). Statistical analyses were performed with a Kruskal-Wallis test, ****: p ? 0.0001, ***: p ? 0.001, **: p ? 0.01. Error bars represent SEM of combined larvae from two independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cancer Lett.