FIGURE

Fig. 6

ID

ZDB-FIG-230614-6

Publication

Grissenberger et al., 2022 - High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-X_L inhibition against Ewing sarcoma

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Fig. 6

Fig. 6. Combination treatments in xenografts with patient-derived cells (IC-pPDX-87) Xenotransplanted larvae were treated with A-1331852 (10 ?M), S63845 (5 ?M), irinotecan (5 ?M), and respective combinations for 48 h (1 dpi - 3 dpi). A) Representative images for average change in tumor size for every condition. B) Relative change in tumor area (3 dpi/1 dpi). C) Mean absolute tumor sizes and percent changes. Scale bar is 125 ?m. Significance is shown as followed: Single treatments were compared to DMSO control. Combination treatments were compared to respective single treatments (top value indicates comparison to first compound, bottom value indicates comparison to second compound). Statistical analyses were performed with a Kruskal-Wallis test, ****: p ? 0.0001, **: p ? 0.01, *: p ? 0.05. Error bars represent SEM of combined larvae (n) of one experiment (single treatments) or two experiments (combinations).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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