FIGURE

Figure 9

ID
ZDB-FIG-230613-40
Publication
Sharma et al., 2023 - β-Catenin Elicits Drp1-Mediated Mitochondrial Fission Activating the Pro-Apoptotic Caspase-1/IL-1β Signalosome in Aeromonas hydrophila-Infected Zebrafish Macrophages
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Figure 9

Overview of the study. Canonical Wnt signaling-induced NOX-mediated ROS triggers mtROS generation leading to downstream ΔΨm loss. ΔΨm loss prompts the activation of Drp1-mediated mitochondrial fission. Activated mitochondrial fission leads to cyt c release, which activates the caspase-1/IL-1β/caspase-3 axis, leading to apoptosis of the A. hydrophila-infected ZKM.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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