FIGURE

Figure 4

ID

ZDB-FIG-230613-34

Publication

Sharma et al., 2023 - β-Catenin Elicits Drp1-Mediated Mitochondrial Fission Activating the Pro-Apoptotic Caspase-1/IL-1β Signalosome in Aeromonas hydrophila-Infected Zebrafish Macrophages

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Figure 4

β-catenin triggers NOX-induced ROS production and upregulates shc2 mRNA expression. (A) ZKM pre-treated with or without NOX inhibitors (Apo and DPI) and β-catenin inhibitor (JW67) for 1 h were infected with A. hydrophila, and superoxide levels were measured using the NBT assay at 6 h p.i., and (B) ZKM pre-treated with or without JW67 for 1 h were infected with A. hydrophila, and shc2 mRNA expression was analyzed with RT-qPCR at 6 h p.i. Vertical bars represent the mean ± SEM (n = 3). Asterisk (*) denotes a significant difference between the indicated groups (* p < 0.05). “+B” mentioned in the X-axis represents “+A. hydrophila”.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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