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ZDB-FIG-230608-25

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Jin et al., 2022 - Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification

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Fig. 4

Fig. 4. Depletion of Cdx1b does not obviously affect the endoderm patterning. A: Patterning of the endoderm-derived organs was not visually altered in cdx1b^zju1^/zju1 at 2 dpf, 3 dpf, and 5 dpf as revealed by WISH using the pan-endodermal markers foxa3, gata4, and gata6 probes. B: Heatmap showing 43 TFs whose expressions were upregulated in 4 cdx1b^zju1/zju1 intestine samples (cdx1b^zju1/zju1-Int) compared with that in three WT intestine samples (wt_Int) (cut-off value: log₂[fold-change] > 2, P < 0.01). Heatmap also shows the expression of these TFs in three WT liver (WT_lv) at 5 dpf. RNA-seq data for three WT_Int and three WT_lv samples were adopted from our recently published report (Gao et al., 2022).

Expression Data

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Antibody Labeling

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Acknowledgments

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Reprinted from Journal of genetics and genomics = Yi chuan xue bao, 49(12), Jin, Q., Gao, Y., Shuai, S., Chen, Y., Wang, K., Chen, J., Peng, J., Gao, C., Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification, 1101-1113, Copyright (2022) with permission from Elsevier. Full text @ J. Genet. Genomics