FIGURE

Figure 8

ID

ZDB-FIG-230518-122

Publication

Parameswaran et al., 2023 - Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

Other Figures

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Figure 8

Proposed pathogenic mechanisms caused by C9ORF72 antisense C₄G₂ repeat expanded RNAs.

C9ORF72 antisense C₄G₂ repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response and lead to neurotoxicity independent of DPR proteins.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Figure 8

Figure 8

Proposed pathogenic mechanisms caused by C9ORF72 antisense C4G2 repeat expanded RNAs.

Proposed pathogenic mechanisms caused by C9ORF72 antisense C₄G₂ repeat expanded RNAs.