FIGURE

Fig. 3

ID

ZDB-FIG-230512-11

Publication

Xia et al., 2022 - Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish

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Fig. 3

Elevated mt2 expression in melanocytes of slc30a1 mutants. A, The 30 significantly changed KEGG pathways revealed by SMART-seq data. Pathways related to cancer development are highlighted by red rectangles. B-C, The GO terms related to pigment or melanocyte development (B) or zinc biology (C) revealed by SMART-seq data. D, Heatmap analysis of genes containing the significantly changed GO terms ?melanosome organization? and ?response to zinc ion?. E, The expression level of mt2 in control and mutant embryos detected by qPCR. F, Whole-mount in situ hybridization of mt2 in control and mutant embryos at different stages. The ysl and pigments in the head are indicated by red arrows. **p < 0.01 and ***p < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Gene:	mt2
Fish:	slc30a1a^zju32/zju32; slc30a1b^zju34/zju34; el2Tg/el2Tg slc30a1a^zju32/zju32; slc30a1b^zju35/zju35; el2Tg/el2Tg slc30a1a^zju33/zju33; slc30a1b^zju34/zju34; el2Tg/el2Tg slc30a1a^zju33/zju33; slc30a1b^zju35/zju35; el2Tg/el2Tg
Anatomical Terms:	head melanoblast whole organism yolk syncytial layer melanoblast
Stage Range:	Long-pec to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc30a1a^zju32/zju32; slc30a1b^zju34/zju34; el2Tg/el2Tg slc30a1a^zju32/zju32; slc30a1b^zju35/zju35; el2Tg/el2Tg slc30a1a^zju33/zju33; slc30a1b^zju34/zju34; el2Tg/el2Tg slc30a1a^zju33/zju33; slc30a1b^zju35/zju35; el2Tg/el2Tg
Observed In:	head melanoblast neural crest melanosome organization neural crest response to zinc ion whole organism yolk syncytial layer melanoblast
Stage Range:	Long-pec to Pec-fin

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Eur. J. Cell Biol.