Gene
mt2
- ID
- ZDB-GENE-030131-4174
- Name
- metallothionein 2
- Symbol
- mt2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular endothelial growth factor production; and response to copper ion. Is expressed in several structures, including digestive system; nervous system; pleuroperitoneal region; vein; and yolk. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to human MT2A (metallothionein 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mt2 | (2) | |
| CRISPR2-mt2 | (2) | |
| CRISPR3-mt2 | Ujiie et al., 2024 | |
| MO1-mt2 | N/A | (2) |
| MO2-mt2 | N/A | Schuermann et al., 2015 |
| TALEN1-mt2 | Schuermann et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Metallothionein domain superfamily | Metallothionein domain superfamily, vertebrate | Metallothionein, vertebrate | Metallothionein, vertebrate, metal binding site |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZSY6 | InterPro | 60 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-102F14 | ZFIN Curated Data | |
| Contains | SNP | rs3728903 | ZFIN Curated Data | |
| Contains | SNP | rs3728904 | ZFIN Curated Data | |
| Contains | SNP | rs3728905 | ZFIN Curated Data | |
| Encodes | EST | fc77e11 | ||
| Encodes | EST | fj10c11 | ||
| Encodes | cDNA | MGC:56534 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174542 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:56508 | ZFIN Curated Data | |
| Is Hybridized by | EST | fi34h02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC049475 (1) | 616 nt | ||
| Genomic | GenBank:BX908765 | 155120 nt | ||
| Polypeptide | UniProtKB:Q7ZSY6 (1) | 60 aa |
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Ujiie, H., Nishiya, N., Yamamoto, A., Takada, T., Onodera, M., Sasaki, A., Oikawa, T. (2024) Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2. Cancer Chemotherapy and Pharmacology. 94(4):561-569
- Zhong, X., Zhang, G., Huang, J., Chen, L., Shi, Y., Wang, D., Zheng, Q., Su, H., Li, X., Wang, C., Zhang, J., Guo, L. (2024) Effects of Intestinal Microbiota on the Biological Transformation of Arsenic in Zebrafish: Contribution and Mechanism. Environmental science & technology. 58(5):2247-2259
- He, X., Ge, C., Xia, J., Xia, Z., Zhao, L., Huang, S., Wang, R., Pan, J., Cheng, T., Xu, P.F., Wang, F., Min, J. (2023) The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 10(17):e2205345
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Bhagat, J., Zang, L., Kaneco, S., Nishimura, N., Shimada, Y. (2022) Combined exposure to nanoplastics and metal oxide nanoparticles inhibits efflux pumps and causes oxidative stress in zebrafish embryos. The Science of the total environment. 835:155436
- Xia, Z., Yang, X., Bi, X., Tong, X., Min, J., Wang, F. (2022) Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish. European journal of cell biology. 101:151272
- Zhu, J., Zhang, Y., Xu, Y., Wang, L., Wu, Q., Zhang, Z., Li, L. (2022) Effects of microplastics on the accumulation and neurotoxicity of methylmercury in zebrafish larvae. Marine Environmental Research. 176:105615
- Dong, N., Bandura, J., Zhang, Z., Wang, Y., Labadie, K., Noel, B., Davison, A., Koene, J.M., Sun, H.S., Coutellec, M.A., Feng, Z.P. (2021) Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis. BMC Genomics. 22:18
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
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