Gene

mt2

ID
ZDB-GENE-030131-4174
Name
metallothionein 2
Symbol
mt2 Nomenclature History
Previous Names
  • mt
  • MT (1)
  • mt1 (1)
  • wu:fc77e11
  • wu:fj10c11
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular endothelial growth factor production; and response to copper ion. Is expressed in several structures, including digestive system; nervous system; pleuroperitoneal region; vein; and yolk. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to human MT2A (metallothionein 2A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Schuermann et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mt2 Human Ortholog
No data available
Associated With mt2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018064 Metallothionein, vertebrate, metal binding site
Family IPR000006 Metallothionein, vertebrate
Family IPR003019 Metallothionein
Homologous_superfamily IPR017854 Metallothionein domain superfamily
Homologous_superfamily IPR023587 Metallothionein domain superfamily, vertebrate
Domain Details Per Protein
Protein Length Metallothionein Metallothionein domain superfamily Metallothionein domain superfamily, vertebrate Metallothionein, vertebrate Metallothionein, vertebrate, metal binding site
UniProtKB:Q7ZSY6 60
UniProtKB:P52722 60
UniProtKB:Q1LV07 60
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations