FIGURE

Fig. 5

ID

ZDB-FIG-230508-99

Publication

Lasbleiz et al., 2022 - Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling

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Fig. 5

PRE-084 enhanced ER stress response in TDP43^G348C-zebrafish. (A) Transcript levels of UPR genes in TDP43^G348C larvae, treated or not with PRE-084 after an ER stress induction with tunicamycin for 24 h. Data from n = 8–9 were presented as mean ± SEM. Statistical analysis was performed by using Student t-test (*p < 0.05). (B) As in (A) but after an ER stress induction for 2 h. Data from n = 6–7 were presented as mean ± SEM. Statistical analysis was performed by using Student t-test (*p < 0.05; **p < 0.01). (C) Western blot showing BiP and ATP5α protein levels larvae expressing TDP43^G348C treated or not with PRE-084 after 2 h with tunicamycin condition. (D) Quantitative analysis of BiP protein levels in zebrafish larvae from (C). ATP5α was used as a reference to normalize BiP levels. Data from 8 to 9 independent samples were averaged and presented as mean ± SEM Statistical analysis was performed by using Student t-test (*p < 0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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