FIGURE

Fig. 7

ID

ZDB-FIG-230508-101

Publication

Lasbleiz et al., 2022 - Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling

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Fig. 7

Increasing NRF2 levels reduced TDP43 toxicity. (A) RNA expression levels of NRF2 in larvae treated or not with sulforaphane. Data from n = 6 were presented as mean ± SEM. Statistical analysis was performed by the Student t-test (**p < 0.01; ***p < 0.001). (B) RNA expression levels of NRF2 targets: GCLC, GCLM, PRDX6 and PGD in larvae treated or not with sulforaphane. Data from n ≥ 5 were presented as mean ± SEM. Statistical analysis was performed by the Student t-test (**p < 0.01; ***p < 0.001). (C) Touch-escape response of control larvae or larvae expressing TDP43^G348C and treated or not with sulforaphane. Data from 25 were averaged and presented as mean ± SEM. Statistical analysis was performed by Tukey's test (*p < 0.05; ***p < 0.001). (D) Touch-escape response of control larvae or larvae expressing TDP43^G348C alone or with NRF2. Data from 25 larvae were averaged and presented as mean ± SEM. Statistical analysis was performed using ANOVA followed by Tukey's test (***p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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