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Fig. 7

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ZDB-FIG-230505-11

Publication

Vicente et al., 2022 - Early calcium and cardiac contraction defects in a model of phospholamban R9C mutation in zebrafish

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Fig. 7

Summary of the pathological model for R9C mutation. PLN^R9C mutation leads to increased Ca²⁺ levels, contractility, and a blunted β-adrenergic response in the heart, consistent with the observations in 3 dpf larvae. The chronic inotropic stimulation caused by R9C, and the energetic demand exerts a pathological effect displaying ventricular dilation, systolic dysfunction, bradycardia and negative lusitropy, as observed in 9 dpf larvae. A reduced antioxidant capacity may alter the redox balance in line with the observation in 9 dpf treated with NAC . Asterisks indicate the findigs shown in this work; the mitochondrial changes are a working model (ETC, electron transport chain; MCU, mitochondrial Ca²⁺ uniporter; ROS, reactive oxygen species).

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Reprinted from Journal of Molecular and Cellular Cardiology, 173, Vicente, M., Salgado-Almario, J., Valiente-Gabioud, A.A., Collins, M.M., Vincent, P., Domingo, B., Llopis, J., Early calcium and cardiac contraction defects in a model of phospholamban R9C mutation in zebrafish, 127-140, Copyright (2022) with permission from Elsevier. Full text @ J. Mol. Cell. Cardiol.