FIGURE

Figure 3

ID

ZDB-FIG-230416-3

Publication

Gopal et al., 2023 - Development of a Triple-Negative Breast Cancer Leptomeningeal Disease Model in Zebrafish

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Figure 3

MDA-MB-231 TNBC cells exhibited increased tumor area in the zebrafish hindbrain ventricle compared to noncancerous breast tissue cells. (A). Top row: images of noncancerous breast tissue MCF10A xenograft cells treated with DiI in the hindbrain ventricle at 1, 4, and 8 dpi; bottom row: images of cancerous breast tissue MDA-MB-231 xenograft cells treated with DiI in the hindbrain ventricle at 1, 4, and 8 dpi. (B). Comparison of MCF10A (white columns) and MDA-MB-231 (orange columns) corrected total cell fluorescence values at 1, 4, and 8 dpi. Key: days postinjection (dpi); corrected total cell fluorescence (CTCF); relative fluorescence units (RFU); p < 0.05, “**” = 0.01; Error bars = SEM; scale bar = 100 µm; N for MCF10A: 27 (1 dpi), 30 (4 dpi), 33 (8 dpi); N for MDA-MB-231: 27 (1 and 4 dpi), 35 (8 dpi).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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