FIGURE

Figure 4

ID

ZDB-FIG-230416-4

Publication

Gopal et al., 2023 - Development of a Triple-Negative Breast Cancer Leptomeningeal Disease Model in Zebrafish

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Figure 4

Doxorubicin treatment decreased tumor area compared to DMSO vehicle in zebrafish MDA-MB-231 TNBC xenografts. (A). Top row: images showing the area occupied by MDA-MB-231-Luc/RFP TNBC cells in zebrafish xenograft samples treated with DMSO vehicle at 1, 4, and 8 days postinjection; bottom row: images showing the area occupied by MDA-MB-231-Luc/RFP TNBC cells in zebrafish xenograft samples treated with 8 µM doxorubicin at 1, 4, and 8 dpf. (B). Measurement of corrected total cell fluorescence for DMSO-treated samples (white columns) and doxorubicin-treated samples (blue columns) at 1, 4, and 8 dpi. Key: CTCF = corrected total cell fluorescence; RFU = relative fluorescence units; Dox = doxorubicin. N = 3 biological replicates with 26–30 total technical replicates. “****” = p < 0.0001; Error bars = SEM. Scale bar = 200 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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