Figure 8—figure supplement 1.
- ID
- ZDB-FIG-230319-83
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- Chen et al., 2023 - Granger causality analysis for calcium transients in neuronal networks, challenges and improvements
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Correlation of the drive and receiving values with the cell position and signal-to-noise ratio, and comparison across neuron groups. (A) The neuronal drive, calculated as the sum of the strength of all outgoing Granger causality (GC) links for each neuron, is not correlated to the neuron position. In data recorded by a two-photon laser scanning microscope, different pixels are scanned across the sample with a very small delay. Panel A shows that the scanning direction and delay do not influence the GC results. (B) The neuronal drive is correlated to the signal-to-noise ratio (SNR) of the calcium traces. It is especially high for medial neurons (in red, r = 0.69 compared to r = 0.45 across all 139 neurons). After computing the new threshold for significance with a corrected null hypothesis and the normalized GC values, the correlation between the drive and SNR decreased. (C) The neuronal drive is significantly higher for motor-correlated neurons than for other neurons (Mann-Whitney U test; ns for not significant when p >0.05, ***** when p <0.0001). This observation suggests that motor-correlated neurons are important drivers of the network activity. (D) The receiving value of a given neuron is defined as the sum of all its incoming GC links. As for the drive, it is not correlated to the cell position. (E) The receiving value is correlated to the SNR. This correlation is reduced when computing the receiving value using the normalized GC values. (F) The receiving value is significantly higher for motor-correlated than for other neurons. This shows strong information flow between the motor-correlated neurons (Mann-Whitney U test; ns when p > 0.05, ***** when p <0.0001). |