FIGURE

Fig. 8

ID

ZDB-FIG-230224-22

Publication

Sahin et al., 2022 - Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases

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Fig. 8

Figure 8. Thermostabilization of hPPARα-LBD, hPPARγ-LBD, and hPPARδ-LBD by carboxylic acid-containing CNSL derivatives. Thermal shift assays of hPPARα-LBD (A) interacting with 25 μM GW7647 or 25 μM CNSL derivatives. Stabilization of the hPPARγ-LBD (B) and the hPPARδ-LBD (C) by 50 μM Rosi (rosiglitazone), 50 μM CAY (CAY10592), or 50 μM CNSL derivatives, respectively. The temperature–response curves were analyzed using the four-parameter dose–response curve function in GraphPad Prism 8 and Tm values were determined. ΔTm values were calculated for each compound relative to DMSO and are listed in the legend. Data points represent mean ± standard error of the mean (SEM) (N = 3).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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