FIGURE

Fig. 1

ID

ZDB-FIG-230214-4

Publication

Caja et al., 2021 - The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

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Fig. 1

LKB1 protein analysis in GBM. (a) LKB1, SOX2, NESTIN, and GFAP immunolocalization in the non-tumoral brain and GBM tissue (representative images; Figure S2 shows more images). Original fluorescent images for the four different protein markers plus DAPI (blue), the 5-color merge, and the complete stained core are shown. The individual protein stainings are converted to brown pseudo-color. Magnification bars: 250 and 20 µm. (b) Glioblastoma, anaplastic astrocytoma, and non-tumoral brain tissue cells were classified into two groups, based on the expression of two different stem cell markers, NESTIN, and SOX2, and an astrocytic differentiation marker, GFAP: SOX2^high/NESTIN^high/GFAP^low (GBM_stem) and SOX2^low/NESTIN^low/GFAP^high (GBM_diff). Note that the GBM_stem group can only be identified in GBM (blue plot) but not in non-tumoral (normal, green plot) or anaplastic astrocytoma (red plot) tissues; significant differences at ****p < 0.0001. DAPI, 4′,6-diamidino-2-phenylindole; GBM, glioblastoma; LKB1, liver kinase B1; n.s., not significant

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Physiol.