FIGURE

Figure 6

ID

ZDB-FIG-230110-23

Publication

Lee et al., 2022 - Ipconazole Disrupts Mitochondrial Homeostasis and Alters GABAergic Neuronal Development in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 6

Potential mechanism of neurodevelopmental toxicity of ipconazole pesticide in zebrafish. The zebrafish embryos treated with ipconazole generate ROS and show evidence of dose-dependent mitochondrial dysfunction and ERK1/2 activation. Ipconazole specifically inhibited the development of GABAergic inhibitory neurons at low doses. In contrast, glutamatergic and dopaminergic neurons remained unaffected, possibly disrupting the interplay among the major neurotransmission systems and uncoordinated neural functions in the central nervous system. High concentrations of ipconazole cause cell death in neuronal and muscle development, reducing the motility and survival of embryos. *** p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.