FIGURE

Figure 2

ID

ZDB-FIG-230110-71

Publication

Lee et al., 2022 - Ipconazole Disrupts Mitochondrial Homeostasis and Alters GABAergic Neuronal Development in Zebrafish

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Figure 2

Ipconazole disrupts mitochondrial genome maintenance and respiratory complexes. (A) mRNA profiling of the genes involved in the mitochondrial DNA replication and transcription, tk2 (a), polg (b), twnk (c), polrmt (d), and mfn2) (f), and a fission marker (dnm1l) (g); (B) mRNA profiling of mitochondrial respiratory complex genes: ndufs4 of Complex I (a), sdha of Complex II (b), uqcrc2b of Complex III (c), cox5ab of Complex IV (d), and atp5fa1 of Complex V (e); (C) confocal images of mitochondria (in green) in the midbrain of 3-dpf Tg(Xla.Eef1a1:mlsEGFP)^cms1 larvae treated with ipconazole at 0 μg/mL (a), and 0.2 μg/mL (b). Scale bar, 50 μm; white arrowhead, neuropil; red arrowhead, periventricular zone. * p < 0.05, ** p < 0.01, *** p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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