FIGURE

Fig 7

ID

ZDB-FIG-221216-10

Publication

Grzegorski et al., 2022 - Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis

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Fig 7

Loss of TF contributes to risk of cardiac tamponade.

(A) Stress was chemically induced in 3 dpf larvae by exposure for 16 hours using 25 μM epinephrine and 0.01% hydrocortisone. Larvae were scored for the presence of erythrocytes in the pericardial space (noted by red arrows) by an observer blinded to genotype. Examples of control (left) and tamponade-positive fish (right) are shown. (B) TF-, prothrombin (f2)- and fibrinogen (fga)-deficient fish all showed significantly elevated rates of tamponade relative to controls. Furthermore, TF- and prothrombin-deficient larvae had comparable rates of tamponade and are both significantly increased relative to fga mutants. Statistical significance by binomial proportion test: * < 0.5, ** < 0.01, *** < 0.001. +/* represents +/+ or +/-.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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