FIGURE

Fig. 7

ID

ZDB-FIG-221212-23

Publication

Motta et al., 2021 - SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype

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Fig. 7

Phenotypic assessment of Spred2 KO mice

(A) Soft X-ray images showing skeletal abnormalities in a Spred2^−/− (KO) mouse compared to an age-matched WT littermate. Arrow labels kyphosis.

(B) X-ray images documenting scoliosis (arrow) in a KO mouse compared to an age-matched WT littermate.

(C) Representative photograph of male littermates at the age of 6 weeks showing growth retardation of a KO mouse (left) compared to an age-matched control animal (right).

(D) Comparison of the head shape of male littermates at the age of 6 months.

(E) Quantification of skull lengths taken from X-ray images (n = 6, each group; ^∗p < 0.05).

(F) Representative photograph showing misaligned incisors in KO mice.

(G) Examples of spleens of mice at the age of 12 months showing a dramatic increase in spleen size of a KO mouse.

(H) Quantification of spleen to body weight ratios in young (6–8 weeks) and old (12 months) mice (n = 8 in each group; ^∗p < 0.05).

(I) Comparison of heart weight to body weight ratios (n = 6 mice in each group; ^∗p < 0.05).

(J) Examples of ventricular arrhythmias in KO mice at the age of 12 months.

(K) Examples of supraventricular arrhythmias in KO mice at the age of 12 months.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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