Fig. 2
- ID
- ZDB-FIG-221208-2
- Publication
- Zhang et al., 2021 - Development of curcumin-loaded zein nanoparticles for transport across the blood-brain barrier and inhibition of glioblastoma cell growth
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Transcytosis of ZpD and ZpD-G23 NPs across an in vitro BBB model. Distribution of coumarin-6 and coumarin-6 labeled ZpD and ZpD-G23 NPs in the filter-free BBB model after incubation (at an equal concentration of 1 μg mL−1 coumarin-6) for 2 (A), 4 (B) and 8 (C) hours at 37 °C (n = 3 in duplicate). Basolateral fluorescence signal represents fraction that crossed the BBB. (D) Basolateral fluorescence signal after incubation of the BBB model with coumarin-6 and coumarin-6 labeled ZpD and ZpD-G23 NPs for 2, 4, and 8 hours. *Significantly different from free coumarin-6; # significantly different from Coumarin6-ZpD NPs, P < 0.05. |