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Fig. 4

ID

ZDB-FIG-221208-4

Publication

Zhang et al., 2021 - Development of curcumin-loaded zein nanoparticles for transport across the blood-brain barrier and inhibition of glioblastoma cell growth

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Fig. 4

Cell viability and colony formation of C6 glioma cells in presence of CUR-ZpD and CUR-ZpD-G23 NPs. (A) Relative viability of C6 glioma cells after incubation with different concentrations of empty ZpD NPs, free curcumin and CUR-loaded ZpD NPs with and without G23 for 24 h. The weight concentration of empty ZpD NPs equals to that of CUR-ZpD-G23 NPs (n = 3). (B) Phase contrast images of C6 glioma cell colonies following soft agar colony formation assay in presence of CUR, CUR-ZpD and CUR-ZpD-G23 NPs for 9 days. (C) Quantification of colony formation assay results, showing suppressive effects of CUR, CUR-ZpD NPs and CUR-ZpD-G23 NPs on colony formation of C6 glioma cells. Control (untreated cells) set at 100%. *Significantly different from control; ^# significantly different from CUR at equivalent CUR concentrations (n = 3 in triplicate, *p < 0.05, **p < 0.005, ^#p < 0.05, ^##p < 0.005).

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