FIGURE

Fig. 1

ID

ZDB-FIG-221119-20

Publication

Wei et al., 2022 - Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

a The goal of this work is to develop selective SaClpP activators. b The synthetic lead compound ZG180 as ClpP activator. c Quantitation of α-casein hydrolysis by SaClpP and HsClpP in the presence of ICG-001 and ZG180, respectively (n = 3 biologically independent experiments). Data are presented as mean ± SD (error bars). X-ray crystal structure of ZG180/SaClpP (d) and ZG180/HsClpP (e) complexes. Side and top views of the structural complexes are displayed. SaClpP is shown in gray cartoon tube, HsClpP is shown in wheat cartoon tube, and ZG180 is shown in cyan sphere. f, g The electron density maps and close view of ZG180 binding in the hydrophobic pockets of SaClpP (f) and HsClpP (g). The fo-fc omit map is contoured at 3.0 Å and colored in green, while the 2fo-fc map is contoured at 1.0 Å and colored in magenta. ZG180 is shown in cyan stick. Hydrogen bonds are indicated with dark dashed lines, and the distance in Å is labeled. Source data are provided as a Source Data file.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.