FIGURE

FIGURE 3

ID

ZDB-FIG-221118-126

Publication

Xia et al., 2022 - COG4 mutation in Saul-Wilson syndrome selectively affects secretion of proteins involved in chondrogenesis in chondrocyte-like cells

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FIGURE 3

Chondrosarcoma cells carrying COG4^p.G516R mutation show different features compared to WT and COG4-KO cells. (A) Representative images of aggregates formed by WT or COG4^p.G516R cells in pellet culture. Bar, 1 mm. (B) Diameter measurement of the spheroids on Day 10 (n = 5). Data were presented as scatter dot plot with mean and SEM. (C) Diameter measurement of the spheroids over 9 days (n = 5). Data were presented as mean with SD. (D) Representative images of H&E staining of spheroids on Day 6. Bar, 300 µm. (E) Representative images of TUNEL assay on Day 4. Bar, 50 µm. (F) Statistical analysis of (E) (n = 7) Data were presented as mean with SD. All experiments were performed in duplicate with similar results. Unpaired two-tailed t-test was used. ****, p < 0.001; **, p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol