FIGURE

Fig. 2

ID

ZDB-FIG-221107-2

Publication

Choo et al., 2021 - Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Fig. 2. Anti-seizure property of curcumin in vivo (A) Timeline of the experimental procedure corresponding to our PTZ behavioural hyperactivity assay. (B & C) Quantification of the total distance travelled (m) and maximum acceleration (m/s²) of 5 dpf zebrafish larvae treated or not with PTZ 12 mM and pre-incubated or not with curcumin at different concentrations (0 – 15 µM) The * ** * marker denotes significance at P < 0.0001 respectively as compared to the 12 mM PTZ only group using one-way Analysis of Variance (ANOVA) followed by Dunnett's post hoc test. (D) Timeline of the experimental procedure corresponding to our behavioural hyperactivity assay using gabra1-/- and gabrg2-/- genetic seizure models. (E, F) Quantification of the maximum acceleration (m/s²) of gabra1 + /+ and -/- (E) or gabrg2 + /+ and -/- (F) larvae. Larvae were incubated with different concentration of curcumin (10 – 15 µM). The * ** * marker denotes significance at P < 0.0001 respectively as compared to the homozygous (-/-) group using one-way Analysis of Variance (ANOVA) followed by Dunnett's post hoc test. VHC (vehicle) treatments correspond to 0.1% DMSO.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biomed. Pharmacother.