FIGURE

Fig. 4

ID

ZDB-FIG-221107-4

Publication

Choo et al., 2021 - Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models

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Fig. 4

Fig. 4. A limited number of analogues are active against genetic seizure models. (A) Timeline of the experimental procedure corresponding to our behavioural hyperactivity assay using gabra1-/- and gabrg2-/- genetic seizure models. (B) Quantification of the maximum acceleration (m/s²) of gabra1 + /+ and -/- (B) or gabrg2 + /+ and -/- (C) larvae. Larvae have been pre-incubated with vehicle (VHC) or different analogues (2 – 5 µM). Green indicates significant changes with the * , * *, * ** and * ** * markers denoting significance at P < 0.05, P < 0.01, P < 0.001 and P < 0.0001 using one-way Analysis of Variance (ANOVA) followed by the Šídák multiple comparison test in a plate wise manner.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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