FIGURE

Fig. 1

ID

ZDB-FIG-221030-1

Publication

Ferre-Fernández et al., 2022 - CRISPR-Cas9-mediated functional dissection of the foxc1 genomic region in zebrafish identifies critical conserved cis-regulatory elements

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Fig. 1

Schematic of human FOXC1, zebrafish foxc1a and foxc1b loci, and developed zebrafish lines. A Schematic drawing of human chromosome 6 aligned with zebrafish chromosomes 2 and 20 showing the positions of the identified conserved elements (filled orange boxes labeled at the top). Exons are indicated with labeled black boxes, while intergenic and intronic regions are shown with dotted lines. Position of rs2745572[A], an SNP associated with primary open-angle glaucoma, is shown in blue on human chromosome 6 and corresponding intergenic regions on zebrafish chromosomes 2 and 20 are marked with blue rectangles. B Schematic drawing showing generated lines and corresponding genomic deletions (sequence gaps are indicated)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Genomics